CpG Methylation Changes within the IL2RA Promoter in Type 1 Diabetes of Childhood Onset
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چکیده
منابع مشابه
CpG Methylation Changes within the IL2RA Promoter in Type 1 Diabetes of Childhood Onset
None of the polymorphic variants of the IL2RA gene found associated with Type 1 Diabetes (T1D) was shown to have a functional effect. To test if the epigenetic variation could play a role at this locus, we studied the methylation of 6 CpGs located within the proximal promoter of IL2RA gene in 252 T1D patients compared with 286 age-matched controls. We found that DNA methylation at CpGs -373 and...
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ژورنال
عنوان ژورنال: PLoS ONE
سال: 2013
ISSN: 1932-6203
DOI: 10.1371/journal.pone.0068093